The effect of CD34 count and clonogenic potential of hematopoietic stem cells on engraftment
- Resource Type
- Authors
- Meltem Tol; Tamer Sarı; Erol Ayyildiz; Pervin Topcuoglu; Muhit Ozcan; Osman Ilhan; Meltem Kurt Yuksel
- Source
- Transfusion and Apheresis Science. 43:315-320
- Subject
- Adult
Male
Adolescent
Cell
CD34
Antigens, CD34
Cell Count
Biology
Transplantation, Autologous
Colony-Forming Units Assay
Andrology
Young Adult
medicine
Humans
Transplantation, Homologous
Clonogenic assay
Aged
Colony-forming unit
Neutrophil Engraftment
Graft Survival
Hematopoietic Stem Cell Transplantation
Hematology
Middle Aged
Hematopoietic Stem Cells
Clone Cells
Transplantation
Haematopoiesis
surgical procedures, operative
medicine.anatomical_structure
Immunology
Female
Stem cell
- Language
- ISSN
- 1473-0502
In this study we have determined that the number of the CD34 (+) cells in the grafts that were infused to 48 patients who underwent autologous and allogeneic hematopoietic cell transplantation and evaluated the number of colony forming units in vitro. Our aim was to determine whether there is a relation between these cell counts and post transplantation engraftment kinetics. A negative correlation was detected (p < 0.05) between the CD34 (+) cell count and all colony forming units. A correlation between the CD34 (+) cell count and the kinetics of engraftment could not be demonstrated. In the autologous group, only a weak negative correlation between the CFU–GEMM and neutrophil engraftment was detected. In the allogeneic group, colony forming units did not determine the engraftment.