Subretinal gene delivery using helper-dependent adenoviral vectors
- Resource Type
- Authors
- Rod Bremner; Rui Guan; Huibi Cao; Robert S. Molday; Simon Lam; Derek van der Kooy; Linda Wu; Rongqi Duan; Jim Hu
- Source
- Cell & Bioscience, Vol 1, Iss 1, p 15 (2011)
Cell & Bioscience
- Subject
- Helper dependent adenoviral
lcsh:Biotechnology
Genetic enhancement
Gene delivery
Biology
Bioinformatics
General Biochemistry, Genetics and Molecular Biology
Viral vector
lcsh:Biochemistry
03 medical and health sciences
0302 clinical medicine
lcsh:TP248.13-248.65
medicine
lcsh:QD415-436
lcsh:QH301-705.5
030304 developmental biology
Cloning
0303 health sciences
Retina
Methodology
3. Good health
Cell biology
medicine.anatomical_structure
lcsh:Biology (General)
Mouse Retina
030221 ophthalmology & optometry
Stem cell
- Language
- ISSN
- 2045-3701
This study describes the successful delivery of helper-dependent adenoviral vectors to the mouse retina with long term and robust levels of reporter expression in the retina without apparent adverse effects. Since these vectors have a large cloning capacity, they have great potential to extend the success of gene therapy achieved using the adeno-associated viral vector.