LAW Trial - The Impact of Local Anesthetics Infiltration in Surgical Wound for Gastrointestinal Procedures (LAW): A Double-Blind, Randomized Controlled Trial
- Resource Type
- Authors
- Alejandro Ramírez-Del Val; Rafael H. Pérez-Soto; Gustavo Romero-Velez; Guillermo Ponce de León-Ballesteros; Fernando Ponce de León-Felix; Paulina Moctezuma; Oscar Santes; Noel Salgado-Nesme
- Source
- Journal of investigative surgery : the official journal of the Academy of Surgical Research. 35(1)
- Subject
- Analgesic
Surgical Wound
Gastrointestinal procedures
law.invention
Double blind
03 medical and health sciences
0302 clinical medicine
Randomized controlled trial
law
medicine
Humans
Prospective Studies
Anesthetics, Local
Abdominal Muscles
Bupivacaine
Pain, Postoperative
business.industry
Surgical wound
medicine.disease
Analgesics, Opioid
Opioid
030220 oncology & carcinogenesis
Anesthesia
030211 gastroenterology & hepatology
Surgery
business
Infiltration (medical)
medicine.drug
- Language
- ISSN
- 1521-0553
Prior studies have suggested that infiltration of local anesthetics reduce the rate of surgical site infections (SSIs). Opioid usage has become an epidemic. Some analgesic modalities, such as epidural analgesia and transversus abdominis plane block are associated with shorter length of stay and lower opioid use. The aim of our study was to assess the relationship between local infiltration of bupivacaine with rates of SSI and pain control.We conducted a prospective, double-blinded randomized controlled trial in patients who underwent open major gastrointestinal procedures from July 2016 to June 2017. Patients were divided into two groups based on administration of 0.5% bupivacaine (Patients in the bupivacaine group required a lower dose of epidural analgesia during the first 24 h (5.3 mcg/kg/h vs. 6.4 mcg/kg/h;There is no clear association between bupivacaine infiltration and reduction of SSI rate according to our study. Wound bupivacaine infiltration is associated with a lower dose of epidural infusion and opioid requirements.