Introduction: Dentists perform a variety of surgical procedures frequently requiring the need for a hemostatic agent, in cases where oral anticoagulants are used.Most cases of postoperative bleeding are easily treated with local measures such as packing with a haemostatic dressing, suturing and pressure are satisfactory. Objectives: the aim of the work is to evaluate the efficacy of Collaplug ® in minimizing postoperative bleeding and pain following tooth extraction in patients under oral anticoagulant therapy. Materials and methods: A prospective study was conducted on a total of 40 adult patients treated with oral anticoagulant therapy, who are in need for tooth extraction. Patients were divided equally into two groups, each group consisting of 20 patients.Group A (Study group): the extraction of the tooth was followed by the application of Collaplug ® prior to suturing of the socket.Group B (Control group): the extraction of the tooth was followed by suturing only. Results: A total of 40 patients 21 female(52%) and 19(48%) male, aged between 30 and 60 years (mean =45) were included in the present study. All patients underwent simple tooth extraction while undergoing oral anticoagulants treatment, in study group: there is clinical sinificane after 2hrs of extraction between both groups MC p=