Stereochemistry of the microbial reduction of ketolactones
- Resource Type
- Authors
- Claudio Fuganti; Stefano Servi; Valentino Piergianni; Antonella Sarra; Giuseppe Pedrocchi-Fantoni; Giovanni Fronza
- Source
- Biotechnology Letters. 16:1047-1052
- Subject
- chemistry.chemical_classification
Ketone
Stereochemistry
organic chemicals
Substrate (chemistry)
Bioengineering
General Medicine
Applied Microbiology and Biotechnology
Yeast
chemistry
Biotransformation
polycyclic compounds
Organic chemistry
heterocyclic compounds
Lactone
Biotechnology
- Language
- ISSN
- 1573-6776
0141-5492
Keto-lactones1–4 have been submitted to the action of a group of selected yeasts. The mode of reduction changes with the structure of the substrate, yielding products with diastereo- and/or enantioselection. The preparation of highly functionalised chiral intermediates in enantiomerically enriched form is envisaged.