Moderate-to-severe Endoscopic Inflammation is Frequent After Clinical Remission in Pediatric Ulcerative Colitis
- Resource Type
- Authors
- Dror Weiner; Michal Yaakov; Lee Abramas; Chen Sarbagili-Shabat; Joram Wardi; Arie Levine
- Source
- Journal of Pediatric Gastroenterology & Nutrition. 72:569-573
- Subject
- Adult
Moderate to severe
medicine.medical_specialty
Pediatric ulcerative colitis
Inflammation
Disease
Activity index
Severity of Illness Index
03 medical and health sciences
0302 clinical medicine
030225 pediatrics
Internal medicine
medicine
Humans
Prospective Studies
Intestinal Mucosa
Risk factor
Child
Retrospective Studies
medicine.diagnostic_test
business.industry
Remission Induction
Gastroenterology
Sigmoidoscopy
Colonoscopy
Endoscopy
Pediatrics, Perinatology and Child Health
Colitis, Ulcerative
030211 gastroenterology & hepatology
medicine.symptom
business
- Language
- ISSN
- 1536-4801
0277-2116
OBJECTIVES Pediatric ulcerative colitis (UC) is characterized by low sustained remission rates and frequent extension of disease even if clinical remission is obtained with therapy. Moderate-to-severe endoscopic activity is a risk factor for relapse while prospective evidence regarding early mucosal healing or persistence of inflammation after remission in children is not available. Our aim was to evaluate if significant inflammation is common after clinical remission and could explain the high relapse rate in pediatric UC. METHODS Pediatric UC patients with clinical remission, defined as pediatric UC activity index (PUCAI) scores