Supplemental figures 1-5: S1 - Identification of MRE11 truncation by mass spectrometry and western blot quantification from Fig 1A. S2 - Western blots of protein levels after chloroquine treatment and densitometry of MRE11 levels after PAN and cycloheximide from Fig. 2C,D S3 - Additional cell death analysis by FACS and western blotting supportive of Figs 2 and 3A, S4 - quantification of western blots in Figure 5B, S5 - Additional western blots supportive of data in Figure 6, and data for generation and characterisation of stable cell lines, with further presentation clonogenic assays for cell lines used in Fig 6.