Reduced expression of the polymeric immunoglobulin receptor in pancreatic and periampullary adenocarcinoma signifies tumour progression and poor prognosis
- Resource Type
- Authors
- Jakob Eberhard; Richard Fristedt; Jacob Elebro; Karin Jirström; Liv Jonsson; Margareta Heby; Björn Nodin; Mathias Uhlén; Alexander Gaber; Yulyana Yudina
- Source
- PLoS ONE, Vol 9, Iss 11, p e112728 (2014)
PLoS ONE; 9(11), pp 112728-112728 (2014)
PLoS ONE
- Subject
- Pathology
Epidemiology
Lymphovascular invasion
lcsh:Medicine
Pathology and Laboratory Medicine
Gastroenterology
Metastasis
Cohort Studies
Medicine and Health Sciences
Periampullary cancer
Medicine
lcsh:Science
Lymph node
Multidisciplinary
Research Support, Non-U.S. Gov't
Receptors, Polymeric Immunoglobulin
Prognosis
Immunohistochemistry
people.cause_of_death
Gene Expression Regulation, Neoplastic
Survival Rate
medicine.anatomical_structure
Oncology
Lymphatic Metastasis
Disease Progression
Cancer Epidemiology
Research Article
Ampulla of Vater
medicine.medical_specialty
Clinical Pathology
Immunology
Real-Time Polymerase Chain Reaction
Statistics, Nonparametric
Pancreatic cancer
Internal medicine
Cancer Detection and Diagnosis
Journal Article
Humans
Clinical Trials
Survival rate
business.industry
lcsh:R
Biology and Life Sciences
medicine.disease
Pancreatic Neoplasms
Biomarker Epidemiology
Periampullary Adenocarcinoma
Tissue Array Analysis
Immune System
Cancer and Oncology
lcsh:Q
Clinical Medicine
business
Polymeric immunoglobulin receptor
people
- Language
- English
- ISSN
- 1932-6203
The polymeric immunoglobulin receptor (pIgR) is a key component of the mucosal immune system that mediates epithelial transcytosis of immunoglobulins. High pIgR expression has been reported to correlate with a less aggressive tumour phenotype and an improved prognosis in several human cancer types. Here, we examined the expression and prognostic significance of pIgR in pancreatic and periampullary adenocarcinoma. The study cohort encompasses a consecutive series of 175 patients surgically treated with pancreaticoduodenectomy for pancreatic and periampullary adenocarcinoma in Malmö and Lund University Hospitals, Sweden, between 2001-2011. Tissue microarrays were constructed from primary tumours (n = 175) and paired lymph node metastases (n = 105). A multiplied score was calculated from the fraction and intensity of pIgR staining. Classification and regression tree analysis was used to select the prognostic cut-off. Unadjusted and adjusted hazard ratios (HR) for death and recurrence within 5 years were calculated. pIgR expression could be evaluated in 172/175 (98.3%) primary tumours and in 96/105 (91.4%) lymph node metastases. pIgR expression was significantly down-regulated in lymph node metastases as compared with primary tumours (p = 0.018). Low pIgR expression was significantly associated with poor differentiation grade (p