Wastewater treatment plants are considered one of the main sources of organic micropollutants. Micropollutant continuous and unregulated release into the environment constitutes a threat to the water environment and human health. In this context, upgrading wastewater treatment seems a suitable option. In this paper, we study how to increase the removal efficiencies for 20 micropollutants by the addition of powdered activated carbon (PAC) to a full-scale membrane bioreactor mainly treating hospital wastewater. In addition, we study if PAC addition improves the overall quality of the final effluent and sludge flocs properties. A special focus is done on the influence of dissolved organic matter in the adsorption of the selected micropollutants on PAC.