Chromatin mobility and relocation in DNA repair
- Resource Type
- Authors
- Samuel Rogers; Noa Lamm; Anthony J. Cesare
- Source
- Trends in Cell Biology. 31:843-855
- Subject
- DNA Repair
DNA repair
Biology
Filamentous actin
Homology directed repair
03 medical and health sciences
chemistry.chemical_compound
0302 clinical medicine
Nuclear Bodies
Organelle
medicine
Humans
DNA Breaks, Double-Stranded
Nuclear membrane
Nuclear pore
030304 developmental biology
Biomolecular Condensates
0303 health sciences
Cell Biology
Chromatin
Cell biology
medicine.anatomical_structure
chemistry
030217 neurology & neurosurgery
DNA
DNA Damage
- Language
- ISSN
- 0962-8924
The nucleus is a dynamic environment containing chromatin, membraneless organelles, and specialized molecular structures at the nuclear membrane. Within the spectrum of DNA repair activities are observations of increased mobility of damaged chromatin and the displacement of DNA lesions to specific nuclear environments. Here, we focus on the role that nuclear-specific filamentous actin plays in mobilizing damaged chromatin in response to DNA double-strand breaks and replication stress. We also examine nuclear pore complexes and promyelocytic leukemia-nuclear bodies as specialized platforms for homology-directed repair. The literature suggests an emerging model where specific types of DNA lesions are subjected to nuclear-derived forces that mobilize damaged chromatin and promote interaction with repair hubs to facilitate specialized repair reactions.