Supplementary Figures: Figure S1. Set of tambjamine analogues investigated; Figure S2. General reaction scheme; Figure S3. 1H NMR (DMSO-d6) of compound 3.HCl; Figure S4. 13C (DMSO-d6) of compound 3.HCl; Figure S5. HRMS (EI) of compound 3; Figure S6. 1H NMR (DMSO-d6) of compound 4.HCl; Figure S7. 13C (DMSO-d6) of compound 4.HCl; Figure S8. 13C dept (DMSO-d6) of compound 4.HCl; Figure S9. HRMS (EI) of compound 4.; Figure S10. 1H NMR (CDCl3) of compound 5.HCl; Figure S11. 13C NMR (CDCl3) of compound 5.HCl; Figure S12. 13C dept NMR (CDCl3) of compound 5.HCl; Figure S13. HRMS (EI) of compound 5.; Figure S14. 1H NMR (CDCl3) of compound 6.HCl; Figure S15. 13C NMR (CDCl3) of compound 6.HCl; Figure S16. HRMS (EI) of compound 6.; Figure S17. 1H NMR (CDCl3) of compound 7.HCl; Figure S18. 13C NMR (CDCl3) of compound 7.HCl; Figure S19. 13C dept NMR (CDCl3) of compound 7.HCl; Figure S20. HRMS (EI) of compound 7.; Figure S21. 1H NMR (CDCl3) of compound 8.HCl; Figure S22. 13C NMR (CDCl3) of compound 8.HCl; Figure S23. 13C dept NMR (CDCl3) of compound 8.HCl; Figure S24. HRMS (EI) of compound 8.; Figure S25. 1H NMR (CDCl3) of compound 9.HCl; Figure S26. 13C NMR (CDCl3) of compound 9.HCl; Figure S27. 13C dept NMR (CDCl3) of compound 9.HCl; Figure S28. HRMS (EI) of compound 9.; Figure S29. 1H NMR (CDCl3) of compound 10.HCl; Figure S30. 13C NMR (CDCl3) of compound 10.HCl; Figure S31. 13C dept NMR (CDCl3) of compound 10.HCl; Figure S32. HRMS (EI) of compound 10; Figure S33. 1H NMR (CDCl3) of compound 11.HOAc; Figure S34. 13C NMR (CDCl3) of compound 11.HOAc; Figure S35. 13C dept NMR (CDCl3) of compound 11.HOAc; Figure S36. HRMS (EI) of compound 11; Figure S37. Dose response curves in A549, DMS53, SW900 and H460 cells; Figure S38. Dose response curves in human lung tumor-derived primay cultures; Figure S39. Array validation using TaqMan gene expression assays; Figure S40. Cell cycle assay by flow cytometry; Figure S41. Western blot of apoptotic markers in the DMS53 cell line; Figure S42. Body weight recording; Supplementary Tables: Table S1. Applied biosystem probes list used for the TaqMan gene expression assays; Table S2. List of altered genes in the cancer drug targets QIAGEN RT2 Profiler Array for the SW900 cell line; Supplementary Materials and Methods: Synthesis and characterization; Cell viability; TaqMan assays; Gene expression; Cell cycle; Western blot; Mice weight.