Enhancement of gold-nanocluster-mediated chemotherapeutic efficiency of cisplatin in lung cancer
- Resource Type
- Authors
- Mengting Chen; Yuchen Lin; Xiaocui Fang; Yanlian Yang; Chen Wang; Mingpeng Liu; Lilusi Ma; Jingyi Liu; Mei Jiang
- Source
- Journal of Materials Chemistry B. 9:4895-4905
- Subject
- Lung Neoplasms
Biomedical Engineering
Deep penetration
Metal Nanoparticles
Antineoplastic Agents
Peptide
02 engineering and technology
010402 general chemistry
01 natural sciences
Micelle
Nanoclusters
In vivo
Cell Line, Tumor
polycyclic compounds
medicine
Humans
General Materials Science
Lung cancer
Cisplatin
chemistry.chemical_classification
Chemistry
Drug Synergism
General Chemistry
General Medicine
021001 nanoscience & nanotechnology
medicine.disease
Xenograft Model Antitumor Assays
0104 chemical sciences
Drug Resistance, Neoplasm
Cancer research
Gold
Delivery system
0210 nano-technology
medicine.drug
- Language
- ISSN
- 2050-7518
2050-750X
A novel delivery system for cisplatin was constructed based on electrostatics-mediated assemblies of gold nanoclusters and PEGylated cationic peptide (cisplatin@GC-pKs). Encapsulated cisplatin in the as-formed micelle like assemblies was observed to demonstrate improved cellar uptake and enhanced chemotherapeutic efficiency in the cisplatin-resistant lung cancer cells. In vivo assays further confirmed that cisplatin@GC-pKs had profound anti-tumor efficiency due to deep penetration and accumulation of nanoscale cisplatin@GC-pKs via the enhanced permeability and retention (EPR) effect at tumor tissues. The constructed cisplatin@GC-pKs in this work demonstrated enhanced anti-tumor activity for lung cancer therapy, as well as a potential treatment strategy for a variety of cisplatin-resistance related malignancies.