International audience; The in vitro lifetime assessment of dental zirconia has been the focus of the researchers in the development of dental zirconia applications. This work mainly studied the cyclic fatigue lifetime in saliva and aging lifetime of three commercial zirconia dental materials: two kinds of 3 mol%-yttria partially stabilized zirconia ST (super translucence) and MT(medium translucence), in which MT contains a small amount of alumina; and a 5 mol% yttria stabilized zirconia TT (tooth translucency). ST and MT materials have higher initial mechanical strength (flexural strength) and initial crack propagation threshold than TT materials and thus have longer cycle fatigue lifetime, but TT has the best aging resistance (no aging) in existing aging procedures. MT has a higher average initial mechanical strength and better aging resistance than the ST samples due to the influence of alumina at the grain boundary, but has lower strength reliability. Finally, the service lifetime of the three materials was evaluated, and some guidance for their use and design is provided by combining the analysis of the collected dental zirconia restorations.