Chloroplast thylakoids reduce glucose uptake and decrease intestinal macromolecular permeability
- Resource Type
- Authors
- Per-Åke Albertsson; Charlotte Erlanson-Albertsson; Marilyn Rayner; Björn Weström; Caroline Montelius; Karolina Gustafsson; Sinan Cem Emek
- Source
- British Journal of Nutrition. 106:836-844
- Subject
- Chloroplasts
Time Factors
Macromolecular Substances
Ovalbumin
Glucose uptake
Medicine (miscellaneous)
3-O-Methylglucose
macromolecular substances
Biology
Thylakoids
environment and public health
Permeability
Intestinal absorption
Rats, Sprague-Dawley
Mice
chemistry.chemical_compound
Spinacia oleracea
polycyclic compounds
Animals
Intestinal Mucosa
Barrier function
Nutrition and Dietetics
Dose-Response Relationship, Drug
food and beverages
Dextrans
Rats
Chloroplast
Glucose
Membrane
Dextran
chemistry
Biochemistry
Area Under Curve
Thylakoid
lipids (amino acids, peptides, and proteins)
- Language
- ISSN
- 1475-2662
0007-1145
Thylakoid membranes, derived from chloroplasts, have previously been shown to retard fat digestion and lower blood glucose levels after oral intake. The purpose of the present study was to investigate the effect of thylakoid membranes on the passage of methyl-glucose, dextran and ovalbumin over rat intestine in vitro using Ussing chambers. The results show that thylakoids retard the passage of each of the test molecules in a dose-dependent way. The thylakoids appear to be attached on the mucosal surface and a mechanism is suggested that the thylakoids delay the passage of the test molecules by sterical hindrance. The present results indicate that thylakoid membranes may be useful both to control intestinal absorption of glucose and to enhance the barrier function of the intestine.