Maintained effect of lipid loading on gene expression in reoxygenated, post-hypoxic conditions. A, GBM cells (U-87 MG) were grown in hypoxia without (LD−) and with LDL (LD+) and then reoxygenated. Shown are genes induced at least 1.1 log2 of fold change (FC) in LD+ vs LD- cells following 6 h of reoxygenation. B, Same analysis as in (A) at 48 h of reoxygenation. C, Expression of the commonly upregulated genes in Tumor CellLD+ vs Tumor CellLD− and Hypoxia +LDL vs Hypoxia, as shown in Additional file 1C, in LD+ vs LD− cells following 6 h of reoxygenation. In all cases, there is a maintained induction by lipid loading. D, Same analysis as in (C) at 48 h of reoxygenation. (PDF 15 kb)