DPYDc.1905 + 1G>A Promotes Fluoropyrimidine-Induced Anemia, a Prognostic Factor in Disease-Free Survival, in Colorectal Cancer
- Resource Type
- Authors
- Gulsah Cecener; Ersin Ozturk; Unal Egeli; Erdem Cubukcu; Berrin Tunca; Tuncay Yilmazlar; Ozkan Kanat; Secil Ak Aksoy; Turkkan Evrensel; Gulcin Tezcan; Adem Alemdar; Adem Deligonul
- Source
- Genetic Testing and Molecular Biomarkers. 25:276-283
- Subject
- 0301 basic medicine
Disease free survival
Chemotherapy
Prognostic factor
business.industry
Colorectal cancer
Anemia
medicine.medical_treatment
Dihydropyridine
Genetic variants
General Medicine
medicine.disease
03 medical and health sciences
030104 developmental biology
0302 clinical medicine
030220 oncology & carcinogenesis
Cancer research
Medicine
DPYD
business
Genetics (clinical)
medicine.drug
- Language
- ISSN
- 1945-0257
1945-0265
Background and Aim: In 10–30% of colorectal cancer (CRC) patients, toxic reactions occur after fluoropyrimidine-based chemotherapy. A dihydropyridine dehydrogenase (DPYD) gene variant, c.1905 + 1G>...