Expression and prognostic potential of ribosome 18S RNA m6A methyltransferase METTL5 in gastric cancer
- Resource Type
- Authors
- Yi Yang; Jingjing Jing; Yuan Yuan; Jingwei Liu; Chenzhong Xing; Zhenshuang Wang
- Source
- Cancer Cell International, Vol 21, Iss 1, Pp 1-16 (2021)
- Subject
- MAPK/ERK pathway
Cancer Research
Methyltransferase
QH573-671
Wnt signaling pathway
Cancer
Neoplasms. Tumors. Oncology. Including cancer and carcinogens
Biology
medicine.disease
Nomogram
Oncology
Prognostic biomarkers
ErbB
Genetics
Cancer research
medicine
Immunohistochemistry
METTL5
Gastric cancer
Cytology
Gene
PI3K/AKT/mTOR pathway
RC254-282
- Language
- English
- ISSN
- 1475-2867
Background Ribosomal RNA N6-methyltransferase METTL5 was reported to catalyze m6A in 18S rRNA. We aimed to investigate the expression and prognostic features of METTL5 in gastric cancer (GC). Methods In this study, 168 GC patients and their corresponding adjacent tissues were collected. Immunohistochemical staining was used to detect the expression of METTL5 protein. Univariate and multivariate Cox analysis were used to dertermine the prognostic role of METTL5 protein in GC, and a nomogram was constructed to evaluate GC patients’ prognosis based on METTL5 expression. Data from TCGA and GEO database were also used to validate the prognostic value of METTL5 in GC patients on mRNA level. We further performed GSEA enrichment analysis to explore the possible function and related pathways related to METTL5. Results METTL5 protein in gastric cancer tissues (GCTs) was significantly decreased compared with adjacent normal tissues (ANTs) and adjacent intestinal metaplasia tissues (AIMTs) (P Conclusions METTL5 protein was decreased in GCTs compared with AIMTs and ANTs, and it may be a potential prognostic biomarker in GC.