Identification of the Nrf2 in the fathead minnow muscle cell line: role for a regulation in response to H
- Resource Type
- Authors
- Xiumei, Chen; Qiuju, Wang; Zhixin, Guo; Yunlong, Zhao; Sha, Luo; Ting, Yu; Dongming, Zhang; Guiqin, Wang
- Source
- Fish physiology and biochemistry. 46(5)
- Subject
- Oxidative Stress
Base Sequence
Gene Expression Regulation
NF-E2-Related Factor 2
Animals
Amino Acid Sequence
Gene Silencing
Hydrogen Peroxide
Muscle, Skeletal
Phylogeny
Salmonidae
Cell Line
- Language
- ISSN
- 1573-5168
The Nrf2 (nuclear factor erythroid 2-related factor 2) plays a central role in cell protection against a wide variety of environmental stressors through the Nrf2-Keap1 (Kelch-like ECH-associated protein 1) pathway, but its involvement in modulation of antioxidant system of fish cell is still largely unexplored. The present study focused on the molecular cloning and silencing of the Nrf2 in the fathead minnow muscle cell line (FHM) in response to the oxidative stress induced by H