The Fas/FasL Signaling Pathway: Its Role in the Metastatic Process and as a Target for Treating Osteosarcoma Lung Metastases
- Resource Type
- Authors
- Nadya, Koshkina; Yuanzheng, Yang; Eugenie S, Kleinerman
- Source
- Advances in experimental medicine and biology. 1258
- Subject
- Osteosarcoma
Fas Ligand Protein
Lung Neoplasms
Tumor Microenvironment
Animals
Humans
Apoptosis
Bone Neoplasms
fas Receptor
Signal Transduction
- Language
- ISSN
- 0065-2598
Understanding how the tumor microenvironment participates in inhibiting or supporting tumor growth is critical for the development of novel therapies. Osteosarcoma (OS) metastasizes almost exclusively to the lung, an organ where Fas ligand (FasL) is constitutively expressed. This chapter focuses on our studies dedicated to the interaction of OS cells with the lung microenvironment. We will summarize our studies conducted over the past 20 years showing the importance of the Fas/FasL signaling pathway to the establishment and progression of OS metastases in the lung. We demonstrated that the FasL