A young child with HIV and unsteady gait: A case report
- Resource Type
- Authors
- Nadine Yazbeck; Rima Hanna-Wakim; Yolla Youssef
- Source
- IDCases
IDCases, Vol 19, Iss, Pp-(2020)
- Subject
- 0301 basic medicine
Pediatrics
medicine.medical_specialty
3TC, Lamivudine
030106 microbiology
Human immunodeficiency virus (HIV)
Unsteady gait
Lopinavir/ritonavir
Infectious and parasitic diseases
RC109-216
Case presentation
medicine.disease_cause
CNS, central nervous system
PI, protease inhibitor
Article
ADH, alcohol dehydrogenase
WHO, World Health Organization
03 medical and health sciences
ART, antiretroviral therapy
0302 clinical medicine
immune system diseases
medicine
030212 general & internal medicine
Young child
business.industry
virus diseases
HIV
Lopinavir-ritonavir
Lopinavir
Antiretroviral therapy
Infectious Diseases
ALDH, aldehyde dehydrogenase
Ritonavir
LPV/r, Lopinavir/ritonavir
business
medicine.drug
AZT, Zidovudine
- Language
- English
- ISSN
- 2214-2509
Background: We would like to raise awareness about the toxicities related to the added excipients present in the oral solution of Liponavir/ritonavir in particular alcohol and propylene glycol. Case presentation: In this case report, we describe an 18 month-old child with a newly diagnosed HIV infection on antiretroviral therapy (ART). She developed shortly after starting the ART unsteady gait and imbalance. Conclusions: The excipient-excipient interaction in Lopinavir/ritonavir may contribute to major toxicities not only in premature neonates and infants; but also in older children specifically from Asian ethnicity. Keywords: HIV, Lopinavir-ritonavir, Unsteady gait