Precision Diagnosis of Maturity-Onset Diabetes of the Young with Next-Generation Sequencing: Findings from the MODY-IST Study in Adult Patients
- Resource Type
- Authors
- Hulya Yilmaz Aydogan; Nurdan Gul; Deniz Kanca Demirci; Ummu Mutlu; Gizem Gulfidan; Kazim Yalcin Arga; Aclan Ozder; Ahmet Adil Camli; Yildiz Tutuncu; Oguz Ozturk; Canan Cacina; Feyza Darendeliler; Sukran Poyrazoglu; Ilhan Satman
- Source
- Subject
- Diabetes Mellitus, Type 2
Mutation
Genetics
Mutation, Missense
Molecular Medicine
High-Throughput Nucleotide Sequencing
Humans
Findings from the MODY-IST Study in Adult Patients.-, Omics : a journal of integrative biology, 2022 [Aydogan H. Y. , Gul N., Demirci D. K. , Mutlu U., Gulfidan G., Arga K. Y. , Ozder A., Camli A. A. , Tutuncu Y., Ozturk O., et al., -Precision Diagnosis of Maturity-Onset Diabetes of the Young with Next-Generation Sequencing]
Molecular Biology
Biochemistry
Biotechnology
- Language
Maturity-onset diabetes of the young (MODY) is a highly heterogeneous group of monogenic and nonautoimmune diseases. Misdiagnosis of MODY is a widespread problem and about 5% of patients with type 2 diabetes mellitus and nearly 10% with type 1 diabetes mellitus may actually have MODY. Using next-generation DNA sequencing (NGS) to facilitate accurate diagnosis of MODY, this study investigated mutations in 13 MODY genes (