Development of a Synthesis Process for a Novel HCV NS5A Inhibitor, Emitasvir
- Resource Type
- Authors
- Yingjun Zhang; Enhuo Huang; Delie An; Xuwen Xiang; Feng Yahui; Hongming Xie; Wanrong Dong; Zhihong Peng; Haiwang Liu; Fang Qinghong
- Source
- Organic Process Research & Development. 25:838-848
- Subject
- chemistry.chemical_classification
010405 organic chemistry
Process development
Stereochemistry
viruses
Hepatitis C virus
Organic Chemistry
Enantioselective synthesis
virus diseases
010402 general chemistry
medicine.disease_cause
01 natural sciences
Small molecule
Desymmetrization
digestive system diseases
0104 chemical sciences
Enzyme
chemistry
medicine
HCV NS5A Inhibitor
Physical and Theoretical Chemistry
NS5A
- Language
- ISSN
- 1520-586X
1083-6160
A new approach to the synthesis of Emitasvir (DAG181), a small molecule hepatitis C virus (HCV) nonstructural protein 5A (NS5A) inhibitor, is described. Enantioselective enzymatic desymmetrization ...