Additional file 3 of PPFIA4 promotes castration-resistant prostate cancer by enhancing mitochondrial metabolism through MTHFD2
- Resource Type
- Authors
- Zhao, Ru; Feng, Tingting; Gao, Lin; Sun, Feifei; Zhou, Qianqian; Wang, Xin; Liu, Junmei; Zhang, Wenbo; Wang, Meng; Xiong, Xueting; Jia, Wenqiao; Chen, Weiwen; Wang, Lin; Han, Bo
- Source
- Subject
- urologic and male genital diseases
- Language
Additional file 3: Supplementary Figures and Legends. Figure S1. PPFIA4 does not alter expression of AR and its target genes in PCa cells. Figure S2. PPFIA4 promotes PCa cell growth in vitro. Figure S3. Androgen deprivation induces mitochondrial dysfunction. Figure S4. The increased expression of several key genes involving one-carbon metabolism in CRPC. Figure S5. MTHFD2 overexpression promotes CRPC cell proliferation and is associated with poor prognosis in PCa patients. Figure S6. PPFIA4 exerts no significant effect on MTHFD2 expression. Figure S7. DS18561882 significantly suppresses PCa cell growth in vitro and in vivo.