Copper-catalyzed denitrogenative N-arylation of sulfoximines and sulfonamides with arylhydrazines
- Resource Type
- Authors
- De-Xun Xie; Delie An; Xinchi Ma; Yingjun Zhang; Chaoyang Liu; Wanrong Dong; Zhihong Peng
- Source
- Tetrahedron. 75:3886-3893
- Subject
- 010405 organic chemistry
law
Chemistry
Organic Chemistry
Drug Discovery
Copper catalyzed
010402 general chemistry
Electron paramagnetic resonance
01 natural sciences
Biochemistry
Combinatorial chemistry
0104 chemical sciences
law.invention
- Language
- ISSN
- 0040-4020
A Cu-mediated ligand-free arylation of NH-sulfoximines and sulfonamides by arylhydrazine hydrochlorides was herein demonstrated. The oxidative transformation provided an easy access towards N-aryl sulfoximines and sulfonamides in high yields (up to 93% yields) with broad functional groups tolerance (up to 36 examples). The protocol was proposed to take place through the free radical pathway based on the results of control reactions and EPR analysis.