The pro-inflammatory effect of triglyceride on human CD4
- Resource Type
- Authors
- Shiyao, Tan; Xiaojie, Feng; Zhangluxi, Liu; Qingfeng, Wang; Qingyan, Jiang; Xingsheng, Ye; Hongxi, Li; Guannan, Su; Chunjiang, Zhou; Yao, Wang; Peizeng, Yang
- Source
- Clinical immunology (Orlando, Fla.). 240
- Subject
- CD4-Positive T-Lymphocytes
Uveitis
Disease Models, Animal
Mice
Behcet Syndrome
Interleukin-17
Animals
Humans
Th17 Cells
Th1 Cells
Triglycerides
Autoimmune Diseases
- Language
- ISSN
- 1521-7035
Aberrant lipid metabolism plays a role in inflammation and progression of autoimmune diseases but the definite mechanism remains unclear. In this study we investigate lipidomic profiles in Behçet's disease (BD) and the role of triglyceride (TAG) in the pathogenesis of autoimmune uveitis. Lipidomics revealed a distinct lipid metabolite profile including increased TAG metabolites in plasma of active BD patients. TAG could stimulate the proliferation, IL-17 and IFN-γ expression by CD4