Evaluation of a Non-aqueous Ibuprofen-Phospholipid Complex Formulation in Rats
- Resource Type
- Authors
- Chunhua, Li; Songlin, Xu; Zhidong, Liu; Lingling, Ding; Xiaobin, Zhao; Robert J, Lee
- Source
- In vivo (Athens, Greece). 30(4)
- Subject
- Gastrointestinal Tract
Male
Rats, Sprague-Dawley
Therapeutic Equivalency
Gastrointestinal Absorption
Drug Compounding
Anti-Inflammatory Agents, Non-Steroidal
Animals
Biological Availability
Ibuprofen
Phospholipids
Rats
- Language
- ISSN
- 1791-7549
In the present study, a non-aqueous ibuprofen-phospholipid complex was developed to reduce the gastrointestinal (GI) toxicity of ibuprofen.A non-aqueous ibuprofen-phospholipid complex (IBU-PC) was prepared by mixing phosal-35SB and ibuprofen. In vitro release behavior was studied using a dissolution apparatus. Irritation to gastrointestinal (GI) tract and pharmacokinetics of IBU-PC were studied in rats.Rapid release of drug occurred with approximately 85% of ibuprofen released from the composition within the first 30 min. The GI injury in IBU-PC-treated rats was minimal compared to those of Advil Liqui-gels-treated group. There was no significant difference between IBU-PC and Motrin-treated groups. The area under the concentration-time curve (AUC0~24) of IBU-PC and Motrin were 366±115 and 391±105 μg/h/ml, respectively. The relative bioavailability of IBU-PC was 94.2%.IBU-PC can decrease GI adverse reaction induced by ibuprofen.