Key Developmental Regulators Suggest Multiple Origins of Pancreatic Beta Cell Regeneration
- Resource Type
- Authors
- Xiangyong Wei; Wenchao Shi; Hao Wang; Jianbo He; Lingfei Luo
- Source
- Zebrafish.
- Subject
- 0303 health sciences
Regeneration (biology)
Biology
biology.organism_classification
Cell biology
03 medical and health sciences
0302 clinical medicine
Animal Science and Zoology
Beta cell
Zebrafish
030217 neurology & neurosurgery
030304 developmental biology
Developmental Biology
Cell mass
- Language
- ISSN
- 1557-8542
Extensive efforts have been done to try to restore the lost β cell mass for the cure of diabetes. Animal models have been established to provide evidences of cellular origins and contextual regulators of β cell regeneration. Here, we used a zebrafish β cell ablation and regeneration model to investigate β cell neogenesis in the first few days after a near-total β cell loss. Regeneration of β cells first occurred within 7 h post-treatment. Developmental regulators such as