Adipocyte extracellular vesicles: rescuers of cardiac mitochondrial stress
- Resource Type
- Authors
- Chantal M. Boulanger; Soazig Le Lay; Xavier Loyer
- Source
- Trends in endocrinology and metabolism: TEM. 33(1)
- Subject
- Chemistry
Endocrinology, Diabetes and Metabolism
Ischemia
Extracellular vesicle
Mitochondrion
medicine.disease
medicine.disease_cause
Extracellular vesicles
Cell biology
Mitochondria
chemistry.chemical_compound
Disease Models, Animal
Extracellular Vesicles
Endocrinology
Adipocyte
medicine
Adipocytes
Animals
Humans
Obesity
Reperfusion injury
Oxidative stress
- Language
- ISSN
- 1879-3061
Nutrient excess induces mitochondrial dysfunction, which participates in obesity-related complications. Obesity also associates with high cardiac oxidative stress, which contributes to myocardial dysfunction. Crewe et al. recently evidenced the pivotal role of adipocyte-derived extracellular vesicles (EVs) in cardiac oxidative stress responses and revealed their unexpected protective effect against ischemia/reperfusion injury.