Serum Levels of Neopterin during Antimicrobial Treatment for Mycobacterium ulcerans Infection
- Resource Type
- Authors
- Sridevi Duggirala; Till F. Omansen; Tjip S. van der Werf; Willemien A. Nienhuis; Ymkje Stienstra; Janine de Zeeuw; Wilson Tuah; K. Mohammed Abass
- Source
- The American Society of Tropical Medicine and Hygiene, 89(3), 498-500
- Subject
- Buruli ulcer
Male
Time Factors
030231 tropical medicine
Disease
Neopterin
Procalcitonin
03 medical and health sciences
chemistry.chemical_compound
0302 clinical medicine
Immune system
immune system diseases
Virology
Clarithromycin
Medicine
Humans
Buruli Ulcer
Randomized Controlled Trials as Topic
0303 health sciences
biology
Mycobacterium ulcerans
030306 microbiology
business.industry
Articles
biochemical phenomena, metabolism, and nutrition
medicine.disease
biology.organism_classification
bacterial infections and mycoses
3. Good health
Anti-Bacterial Agents
Infectious Diseases
Treatment Outcome
chemistry
Case-Control Studies
Immunology
Parasitology
Female
Leprosy
business
medicine.drug
- Language
- English
- ISSN
- 1476-1645
Neopterin is closely associated with activation of the cellular immune system. Neopterin levels differed between controls and patients with Buruli ulcer disease. No differences between patients with or without paradoxical responses were observed. Therefore, neopterin has no value in detecting paradoxical responses among patients with limited Buruli ulcer disease. Neopterin levels were lower in patients receiving clarithromycin. This finding might indicate a slower cellular immune recovery, with possible consequences in future therapy with clarithromycin.