The prognostic value of glomerular immaturity in the nephrotic syndrome in children
- Resource Type
- Authors
- Wiesława Salwa-Żurawska; Maciejewski J; Jacek Zachwieja; Aldona Woźniak; Danuta Ostalska-Nowicka
- Source
- Pediatric Nephrology. 19:633-637
- Subject
- Male
Nephrology
Pediatrics
medicine.medical_specialty
Nephrotic Syndrome
Kidney Glomerulus
Serum albumin
Fluorescent Antibody Technique
Disease
Internal medicine
medicine
Humans
Age of Onset
Child
Serum Albumin
First episode
medicine.diagnostic_test
biology
business.industry
Remission Induction
Infant
Steroid resistance
Prognosis
medicine.disease
Microscopy, Electron
Endocrinology
Child, Preschool
Pediatrics, Perinatology and Child Health
biology.protein
Mesangial proliferative glomerulonephritis
Female
Steroids
Renal biopsy
business
Nephrotic syndrome
- Language
- ISSN
- 1432-198X
0931-041X
The study group consisted of 16 children (9 boys and 7 girls) aged 6-52 months (mean age 27 months) with a first episode of nephrotic syndrome. Histological diagnosis (diffuse mesangial proliferation with signs of glomerular immaturity) was established by renal biopsy. The control group consisted of 47 children (26 boys and 21 girls) aged 7-58 months (mean 29 months) hospitalized with a first episode of nephrotic syndrome with diffuse mesangial proliferation, documented exclusively by histological examination. The aim of the study was to analyze the clinical course of a first episode of nephrotic syndrome in children with diffuse mesangial proliferation with and without signs of glomerular immaturity. In children with a first episode of the nephrotic syndrome and glomerular immaturity steroid resistance was more frequent (P=0.0234). Furthermore, in the study group there was a less favorable clinical course of the disease in children younger than 1 year of age and with an original serum albumin concentration lower than 1.0 g/dl. Hence, the presence of relatively rare signs of glomerular immaturity influences unfavorably the course and treatment of nephrotic syndrome in children.