Proton therapy is becoming increasingly popular worldwide, and its shielding must be considered. The cathode ray tube (CRT) material is a glass containing heavy metal elements, these materials have become a good choice for the production of radiation-proof concrete. In this study, the ability of concrete containing CRT fragments as shielding materials for proton therapy rooms is evaluated in terms of neutron shielding ability, neutron reflection ability, ambient dose equivalent rate, and induced radioactivity. In addition, this concrete is compared with commonly used ordinary concrete, boron-containing concrete, and barite concrete. The results show that with the increase of CRT content (10%-90%), the transmitted neutron fluence decreases continuously (5.06 × 10