Plasma fibrinogen associates independently with total and cardiovascular mortality among subjects with normal and reduced kidney function in the general population
- Resource Type
- Authors
- Hoang T. Nguyen; Cornelius J. Cronin; Ailish Hannigan; Astrid Weiland; Ahad A. Abdalla; Austin G. Stack; Urszula Donigiewicz; Liam F. Casserly
- Source
- QJM : monthly journal of the Association of Physicians. 107(9)
- Subject
- Male
medicine.medical_specialty
dialysis patients
Population
Renal function
predictor
equation
Fibrinogen
Kidney Function Tests
Gastroenterology
Severity of Illness Index
serum creatinine
Risk Factors
Internal medicine
Cause of Death
Severity of illness
medicine
Confidence Intervals
Humans
Mortality
Renal Insufficiency, Chronic
education
Cause of death
Proportional Hazards Models
education.field_of_study
glomerular-filtration-rate
business.industry
Proportional hazards model
General Medicine
Middle Aged
Nutrition Surveys
Confidence interval
products
Endocrinology
Quartile
Cardiovascular Diseases
Female
atherosclerosis
business
coronary-heart-disease
nontraditional risk-factors
Ireland
individual participant metaanalysis
medicine.drug
- Language
- ISSN
- 1460-2393
Background: The contribution of novel risk factors to mortality in chronic kidney disease remains controversial. Aim: To explore the association of plasma fibrinogen with mortality among individuals with normal and reduced kidney function. Methods: We identified 9184 subjects, age 40 and over from the Third National Health and Nutrition Examination Survey (1988-94) with vital status assessed through 2006. Plasma fibrinogen was modeled as continuous variable and in quartile groups (0 to = mu mol/l) with total and cardiovascular mortality across categories of glomerular filtration rate (eGFR); 90 ml/min/1.73m(2) using Cox regression. Results: In multivariate analysis, the adjusted hazard ratio (HR) per 1 mu mol/l (34 mg/dl) increase in fibrinogen was 1.07 [95% confidence interval (CI) 1.04-1.09] for total mortality and 1.06 (95% CI 1.03-1.09) for cardiovascular mortality. The adjusted HR for total mortality was 1.05 (1.01-1.09) for subjects with eGFR 60-90 ml/min/1.73m(2) and 1.06 (1.02-1.10) for subjects with eGFR 90, 60-90 and