Additional file 1. Table S1. Epidemiological and hemodynamic data in the entire cohort, and in survivors and nonsurvivors. Table S2. Independent determinants of mortality according to a mixed-effect model, in which hospitals (centers) were added as the random term. Figure S1. Frequency of the variables utilized as a guide for the additional administration of fluids after the initial bolus. Figure S2. Vasopressors and/or inotropes used in the resuscitation of septic patients. Figure S3. Type of solution used for the initial fluid bolus of 30 mL/kg. Tests used for the dynamic assessment of fluid responsiveness.