The aim of this study was to assess the inter-rater variability of the visual interpretation ofA total of 162Complete agreement of visual interpretation by the three raters was observed for 91.3% of the cases (Cohen κ = 0.88 on average) in ternary criteria and for 92.3% (κ = 0.89) in binary criteria. Cases that were interpreted as visually positive in the consensus read showed significantly higher mcSUVR than those visually negative (2.21 ± 0.37 vs. 1.27 ± 0.09, p 0.001), and positive or negative decision by visual interpretation was dichotomized by a cut-off value of mcSUVR = 1.5. Significant positive/negative associations were observed between mcSUVR and the number of raters who evaluated as positive (ρ = 0.87, p 0.0001) and negative (ρ = -0.85, p 0.0001) interpretation. Cases of disagreement among raters showed generally low mcSUVR.Inter-rater agreement was almost perfect in