Additional file 1 of Human placental proteomics and exon variant studies link AAT/SERPINA1 with spontaneous preterm birth
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- Tiensuu, Heli; Haapalainen, Antti M.; Tissarinen, Pinja; Pasanen, Anu; Määttä, Tomi A.; Huusko, Johanna M.; Ohlmeier, Steffen; Bergmann, Ulrich; Ojaniemi, Marja; Muglia, Louis J.; Hallman, Mikko; Rämet, Mika
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Additional file 1: FigS1. Representative 2D gel of human placental tissue after spontaneous preterm birth. FigS2. Densitometric evaluation of western blot of alpha-1 antitrypsin and tubulin α-1B. FigS3. Proteomic differences between chorionic and basal plates of the placenta. FigS4. Immunoelectron microscopy images of localization of AAT and fibronectin in spontaneous term birth placenta. FigS5. Colocalization fluorescence image of AAT and Rab7, and AAT and CD63. FigS6. mRNA expression levels after gene knockdown of SERPINA1. FigS7. Gene expression changes after SERPINA1 silencing according to RNA sequencing and qPCR. TableS1. Protein levels and statistical significance in comparisons of spontaneous preterm and term birth. TableS2. Protein levels and statistical significance in comparisons of spontaneous and elective preterm birth. TableS3. Protein identification. TableS4. Upregulated genes after SERPINA1 silencing in HTR8/SVneo cells. TableS5. Downregulated genes after SERPINA1 silencing in HTR8/SVneo cells. TableS6. Biological pathways affected by SERPINA1 silencing in HTR8/SVneo cells. TableS7. Gene Ontology Biological Processes (GO-BP) term enrichment analysis of genes affected by SERPINA1 silencing. TableS8. Gene Ontology Cellular Component (GO-CC) term enrichment analysis of genes affected by SERPINA1 silencing. TableS9. Comparison of RNA sequencing and qRT-PCR of genes affected by SERPINA1 knockdown.