Anti-NDV activity of baicalin from a traditional Chinese medicine in vitro
- Resource Type
- Authors
- Yan, Jia; Ruiguang, Xu; Yanchun, Hu; Tianlong, Zhu; Tingting, Ma; Haihong, Wu; Liwen, Hu
- Source
- The Journal of Veterinary Medical Science
- Subject
- Flavonoids
Pharmacology
newcastle disease virus (NDV)
animal structures
Full Paper
animal diseases
viruses
Newcastle Disease
Newcastle disease virus
apoptosis
Chick Embryo
biochemical phenomena, metabolism, and nutrition
In Vitro Techniques
Antiviral Agents
Virus inhibitory rate
embryonic structures
Animals
Baicalin
- Language
- ISSN
- 1347-7439
The purpose of this study was to investigate the anti-Newcastle disease virus (NDV) activities of baicalin from Scutellaria baicalensis, a Traditional Chinese Medicine in vitro. Chicken embryo fibroblasts (CEFs) were infected with NDV, and quantitative analysis of apoptotic cells was performed using flow cytometry. Cytotoxicity and anti-viral activities of baicalin were studied using the MTT method. The results showed that the maximal safe concentrations of baicalin to CEFs was 1 × 2(-2) mg/ml. Baicalin could directly kill NDV, inhibit the infectivity of NDV to CEF and block intracellular NDV. It inhibited the apoptosis of NDV-infected CEFs and suppressed the spread of NDV. These results indicate that baicalin has strong anti-NDV activity and has the potential for use as components of an antiviral drug.