Supplementary Figure S1. KP4-derived 3D spheroids with histopathological characteristics of micrometastases show differential sensitivity to small molecule inhibitors; Supplementary Figure S2. Cobimetinib/ponatinib co-treatment increases death of pancreatic cancer cells; Supplementary Figure S3. Cobimetinib/ponatinib co-treatment impairs tumor growth in KPP xenografts; Supplementary Table S1. List of small molecule inhibitors used in drug screen; Supplementary Table S2. Genotype with key mutations of cell lines used in this study; Supplementary Table S3. Tumor growth inhibition (%TGI) of KP4 and KPP xenografts; Supplementary Table S4. TCGA microarray data for normal and PDAC tissues