Fine mapping and sequencing of a variable segment in the inverted repeat region of varicella-zoster virus DNA
- Resource Type
- Authors
- John Hay; W T Ruyechan; William C. Reinhold; M N Flora; T A Casey; Sharon E. Straus
- Source
- Subject
- Herpesvirus 3, Human
Sequence analysis
Inverted repeat
viruses
Immunology
Microbiology
Genome
DNA sequencing
Restriction fragment
chemistry.chemical_compound
Species Specificity
Virology
Repetitive Sequences, Nucleic Acid
Genetics
biology
integumentary system
Nucleic acid sequence
virus diseases
Spacer DNA
chemistry
Insect Science
DNA, Viral
biology.protein
DNA
Research Article
- Language
- English
A strain variation in the internal and terminal repeats which bind the short unique sequence of varicella-zoster virus (VZV) DNA was found to be due to an insertion or deletion of DNA sequences at a single site. DNA sequence analysis showed that the nucleotide sequence CCGCCGATGGGGAGGGGGCGCGGTACC is tandemly duplicated a variable number of times in different VZV strains and is responsible for the observed variation in mobilities of restriction fragments from this region of VZV DNA. The variable region sequence shares some homology with tandemly repeated regions in the a and c sequences of herpes simplex virus type 1 and probably exists in a noncoding region of the VZV genome.