Glucocorticoid receptor signaling in breast and prostate cancers: emergence as a therapeutic target
- Resource Type
- Authors
- Kach, Jacob; Conzen, Suzanne D; Szmulewitz, Russell Z
- Source
- Subject
- Male
Cell Survival
Estrogen Receptor alpha
Prostatic Neoplasms
Breast Neoplasms
Prognosis
Article
Gene Expression Regulation, Neoplastic
Translational Research, Biomedical
Receptors, Glucocorticoid
Receptors, Androgen
Animals
Humans
Female
Signal Transduction
- Language
- English
Steroid receptors for androgens and estrogens have essential roles in prostate and breast cancers. Recently, glucocorticoid receptor (GR) activity has also been proposed as having an important role in these cancers. Underscoring the cooperative nature of nuclear receptor activity, data now suggest that GR function in prostate and breast cancers is dependent on the tumor's concomitant androgen or estrogen receptor activity.