Blood-brain barrier dysfunction in a boxer with chronic traumatic encephalopathy and schizophrenia
- Resource Type
- Authors
- Michael Farrell; Chris H. Greene; Matthew Campbell; Susan Aherne; Eoin O'Keeffe; Sean O'Riordan
- Source
- Clinical neuropathology. 38(2)
- Subject
- Pathology
medicine.medical_specialty
Traumatic brain injury
tau Proteins
Fibrinogen
Blood–brain barrier
Pathology and Forensic Medicine
Chronic Traumatic Encephalopathy
Pathogenesis
03 medical and health sciences
0302 clinical medicine
medicine
Humans
Tight junction
business.industry
Brain
Neurodegenerative Diseases
General Medicine
medicine.disease
Extravasation
Chronic traumatic encephalopathy
medicine.anatomical_structure
Neurology
Schizophrenia
Blood-Brain Barrier
Neurology (clinical)
business
030217 neurology & neurosurgery
medicine.drug
- Language
- ISSN
- 0722-5091
Chronic traumatic encephalopathy (CTE) is a neurodegenerative condition characterized by the perivascular deposition of phosphorylated τ (p-τ) protein aggregates resulting from repetitive mild traumatic brain injury (rTBI). Advances in the field have revealed the significance of repetitive head trauma in the pathogenesis of CTE in contact sports as well as military veterans. In this study we provide evidence of blood-brain barrier (BBB) disruption in regions of intense perivascular p-τ deposition in a former professional boxer diagnosed with CTE and schizophrenia. P-τ deposition was associated with loss of the tight junction protein claudin-5 and enhanced extravasation of endogenous blood components such as fibrinogen and IgG. We also provide evidence of tight junction disruption in individuals with schizophrenia, with discontinuous claudin-5 immunoreactivity in the parietal cortex. This data highlights a common phenotype of a dysfunctional BBB in individuals with CTE and schizophrenia and may represent a novel correlate of neural dysfunction in individuals at risk of developing CTE and schizophrenia. .