Mycotoxigenic fungi, such as species of Aspergillus, Fusarium, and Penicillium, not only cause crop damage and economic loss to the grower but also pose a serious threat to human and livestock health due to the contamination of commodities with carcinogenic and neurotoxic secondary metabolites such as aflatoxins, fumonisins, and trichothecenes. Biocontrol presents an agronomically sustainable and environmentally safe method of containing mycotoxin contamination of food and feed crops. This review is focused on the use of Bacillus species in the control of mycotoxin contamination in maize, a very important cereal crop grown across the world. Bacilli offer several advantages, including their ability to form spores and amenability for formulation into stable products for effective field application.