An emerging area of biology and engineering is nanobiotechnology. Due to its environmental friendliness, using green chemistry to design and develop biocompatible nanoparticles is always a better option. The green chemistry method for making metal nanoparticles has a number of advantages over traditional synthetic techniques, including being easier, safer, quicker, more energy-efficient, mostly one-pot processes, less expensive, and less toxic. Noble nanoparticles (gold, silver, and platinum) are particularly appealing in biomedical applications due to the presence of unusual physicochemical properties, ease of synthesis and surface modification in the nanoscale range, biocompatibility, and a number of other benefits. Gold nanoparticles (AuNPs) are particularly attractive because they are biocompatible. recent discoveries Although the SARS-corona virus 2 infections do not primarily affect the skin, they do in some way, either directly or indirectly, exacerbate skin eruptions. Recent research has shown that curcumin-mediated generated AgNPs may play a role in RSV entrance by inhibiting interactions with the viral surface and damaging viral protein. Copper iodide floral extract (CuI-FE), which has strong COVID-19 inhibitory action, was developed via contemporary molecular docking research. Numerous studies show that green synthesis-mediated nanoparticles including silver, gold, zinc, copper, iron, titanium dioxide, selenium, and cadmium have a strong anti-viral effect. The anti-oxidant, anti-viral, antiinflammatory, anti-hive rich plant-mediated nanoparticle synthesis was used to treat the skin condition caused by SARS-corona virus 2 (the viral clinical signs are itchy, hives, rashes, papules, psoriasis, and inflammation) and (non-viral clinical signs-pressure urticaria, contact dermatitis, and acne).