Additional file 1: Figure S1. Female mice exhibit exacerbated anxiety following predator odor stress. Figure S2. Physical stress in mice leads to induction of cleaved Caspase 1 in amygdala and hippocampus. Figure S3. Inhibition of NLRP3 inflammasome by treating stressed mice with MCC950 attenuates IL1�� and Caspase 1 activity in amygdala. Figure S4. Inhibition of BTK with LFM-A13 in physically stressed mice provided protection from hyper-anxious behavior and inhibited the proinflammatory pathway.