S1: Analysis of p50 NF-κB ablation in myeloid cells (p50Fl/Fl; Lyz2Cre mice) and enterocytes (p50Fl/Fl; VillinCre mice). S2: Analysis of inflammatory gene expression at different phases of colitisassociated CRC (CAC) development. S3: Lack of p50 NF-κB exacerbates DSS-induced colitis. S4: Genetic ablation of p50 unleashes anti-tumor M1-polarized activation of TAMs. S5: Lack of p50 shapes gut associated immune populations in AOM/DSS treated. S6: Lack of p50 selectively impairs lamina propria monocytes/macrophages accumulation in steady state conditions. mice. S7: Wt and p50-/- mice show similar levels of proliferative colonic cancer cells. S8: Nuclear accumulation of p50 in TAM at the inner tumor tissue does not correlate with CRC patients' outcome.