Oxidation of the Methyl Group at the Aromatic Nucleus with Molecular Oxygen in the Presence of N-Bromosuccinimide under Photoirradiation
- Resource Type
- Authors
- Tomohiro Kodama; Yukio Masaki; Akichika Itoh; Shouei Hashimoto
- Source
- ChemInform. 35
- Subject
- chemistry.chemical_classification
Hydrogen
Carboxylic acid
Organic Chemistry
food and beverages
chemistry.chemical_element
General Medicine
Photochemistry
Medicinal chemistry
Oxygen
Catalysis
chemistry.chemical_compound
medicine.anatomical_structure
chemistry
embryonic structures
medicine
Molecular oxygen
N-Bromosuccinimide
Nucleus
Methyl group
- Language
- ISSN
- 1522-2667
0931-7597
A methyl group at the aromatic nucleus can be oxidized to the corresponding carboxylic acid directly in the presence of N-bromosuccinimide (NBS) under photoirradiation. By considering both the promoting effect of oxygen and a catalytic amount of NBS, aerobic oxidation via hydroperoxide, which is thought to be generated by abstraction of a hydrogen with a bromo radical from NBS, proceeded.