A Laser Driven Flow Chemistry Platform for Scaling Photochemical Reactions with Visible Light
- Resource Type
- Authors
- Eric G. Moschetta; Shailendra Bordawekar; Kaid C. Harper; Steven J. Wittenberger
- Source
- ACS Central Science, Vol 5, Iss 1, Pp 109-115 (2019)
ACS Central Science
- Subject
- Materials science
General Chemical Engineering
Flow (psychology)
Continuous stirred-tank reactor
General Chemistry
Flow chemistry
Laser
Photochemistry
Catalysis
law.invention
Chemistry
Organic reaction
law
Reactivity (chemistry)
Throughput (business)
QD1-999
Research Article
- Language
- English
- ISSN
- 2374-7951
Visible-light-promoted organic reactions can offer increased reactivity and selectivity via unique reaction pathways to address a multitude of practical synthetic problems, yet few practical solutions exist to employ these reactions for multikilogram production. We have developed a simple and versatile continuous stirred tank reactor (CSTR) equipped with a high-intensity laser to drive photochemical reactions at unprecedented rates in continuous flow, achieving kg/day throughput using a 100 mL reactor. Our approach to flow reactor design uses the Beer–Lambert law as a guideline to optimize catalyst concentration and reactor depth for maximum throughput. This laser CSTR platform coupled with the rationale for design can be applied to a breadth of photochemical reactions.
A continuous stirred tank reactor was equipped with a high-intensity laser to drive photochemical reactions at unprecedented rates in continuous flow, achieving kg/day throughput.