Designing a Novel Functional Peptide With Dual Antimicrobial and Anti-inflammatory Activities
- Resource Type
- Authors
- Min Kyoung, Shin; Byungjo, Lee; Seung Tae, Kim; Jung Sun, Yoo; Jung-Suk, Sung
- Source
- Frontiers in immunology. 13
- Subject
- Lipopolysaccharides
Anti-Infective Agents
Anti-Inflammatory Agents
Anti-Bacterial Agents
Antimicrobial Cationic Peptides
- Language
- ISSN
- 1664-3224
As spider venom is composed of various bioactive substances, it can be utilized as a platform for discovering future therapeutics. Host defense peptides are great candidates for developing novel antimicrobial agents due to their multifunctional properties. In this study, novel functional peptides were rationally designed to have dual antibacterial and anti-inflammatory activities with high cytocompatibility. Based on a template sequence from the transcriptome of spider