Additional file 1 Supplementary methods. Table S1 Model reconstruction from synthetic data. Table S2: Reconstruction Error (RE) comparison in BRCA and OV. Table S3: Exposure Reconstruction Error (ERE) comparison in BRCA and OV. Figure S1: De-novo signatures from MSK-IMPACT. Figure S2: Clusters learned from MSK-IMPACT. Figure S3: Signature discovery from MSK-IMPACT. Figure S4: Signature discovery comparison with SomaticSignatures.