Galleria mellonella as a screening tool to study virulence factors of Aspergillus fumigatus
- Resource Type
- Authors
- Elise Melloul; Marie-Laure Dardé; Françoise Botterel; Marie-Fleur Durieux; Eric Dannaoui; Jacques Guillot; Lolita Roisin; Sana Jemel
- Source
- Virulence, Vol 12, Iss 1, Pp 818-834 (2021)
Virulence
article-version (VoR) Version of Record
Virulence, 2021, 12 (1), p. 818-834. ⟨10.1080/21505594.2021.1893945⟩
- Subject
- Microbiology (medical)
animal structures
mini-host model
Immunology
Mutant
review
virulence factors
Virulence
Review Article
Infectious and parasitic diseases
RC109-216
Microbiology
Aspergillus fumigatus
03 medical and health sciences
Screening tool
030304 developmental biology
galleria mellonella
0303 health sciences
biology
030306 microbiology
fungi
aspergillus fumigatus
biochemical phenomena, metabolism, and nutrition
biology.organism_classification
Pathogenicity
Galleria mellonella
Infectious Diseases
[SDV.SPEE] Life Sciences [q-bio]/Santé publique et épidémiologie
[SDV.SPEE]Life Sciences [q-bio]/Santé publique et épidémiologie
Parasitology
- Language
- English
- ISSN
- 2150-5608
2150-5594
International audience; The invertebrate Galleria mellonella has increasingly and widely been used in the last few years to study complex host-microbe interactions. Aspergillus fumigatus is one of the most pathogenic fungi causing life-threatening diseases in humans and animals. Galleria mellonella larvae has been proven as a reliable model for the analysis of pathogenesis and virulence factors, enable to screen a large number of A. fumigatus strains. This review describes the different uses of G. mellonella to study A. fumigatus and provides a comparison of the different protocols to trace fungal pathogenicity. The review also includes a summary of the diverse mutants tested in G. mellonella, and their respective contribution to A. fumigatus virulence. Previous investigations indicated that G. mellonella should be considered as an interesting tool even though a mammalian model may be required to complete and verify initial data.