Associations between seroprevalence of Helicobacter pylori and ABO/rhesus blood group antigens in healthy blood donors in southwest Iran
- Resource Type
- Authors
- Azar Dokht Khosravi; Mehrandokht Sirous; Morteza Saki; Sakineh Seyed-Mohammadi; Seyed Reza Modares Mousavi; Hojat Veisi; Asma Abbasinezhad Poor
- Source
- The Journal of International Medical Research
- Subject
- Antigens, Bacterial
Helicobacter pylori
seroprevalence
Biochemistry (medical)
ABO blood group
Blood Donors
Enzyme-Linked Immunosorbent Assay
Cell Biology
General Medicine
Iran
bacterial infections and mycoses
Biochemistry
Antibodies, Bacterial
ABO Blood-Group System
Helicobacter Infections
Pre-Clinical Research Report
Bacterial Proteins
cytotoxin-associated gene A
Seroepidemiologic Studies
Humans
- Language
- English
- ISSN
- 1473-2300
0300-0605
Objective To investigate correlations between ABO/rhesus (Rh) blood group antigens and anti- Helicobacter pylori and anti-cytotoxin-associated gene A (CagA) seropositivity in blood donors. Methods A total of 311 blood donors were enrolled. ABO and Rh blood groups were determined using hemagglutination tests. Specific anti- H. pylori IgG and anti-CagA IgG antibodies in sera were quantitated by enzyme-linked immunosorbent assay. Correlations between blood groups and anti- H. pylori and anti-CagA seropositivity were evaluated using the Chi-square test. Results O+ was the most frequent blood type (38%, n = 118). Anti- H. pylori IgG seropositivity was observed in 240 (77.2%) blood donors, while anti-CagA IgG seropositivity was observed in 132 (42.5%) blood donors. Although seropositivity rates for both anti- H. pylori and anti-CagA IgG were higher in individuals with blood type O, no statistically significant associations were observed between seropositivity and any ABO/Rh blood groups. Conclusion Individuals with blood type O may have higher rates of H. pylori seropositivity.